Phosphorylated α-synuclein in skin nerve fibres differentiates Parkinson's disease from multiple system atrophy.

@article{Zange2015PhosphorylatedI,
  title={Phosphorylated α-synuclein in skin nerve fibres differentiates Parkinson's disease from multiple system atrophy.},
  author={Leonora Zange and Cornelia Noack and Katrin Hahn and Werner Stenzel and Axel Lipp},
  journal={Brain : a journal of neurology},
  year={2015},
  volume={138 Pt 8},
  pages={2310-21}
}
Deposition of phosphorylated SNCA (also known as α-synuclein) in cutaneous nerve fibres has been shown pre- and post-mortem in Parkinson's disease. Thus far, no pre-mortem studies investigating the presence of phosphorylated SNCA in skin sympathetic nerve fibres of multiple system atrophy, another synucleinopathy, have been conducted. In this in vivo study, skin from the ventral forearm of 10 patients with multiple system atrophy and 10 with Parkinson's disease, together with six control… CONTINUE READING

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