Phosphorylated α-Synuclein Accumulations and Lewy Body-like Pathology Distributed in Parkinson’s Disease-Related Brain Areas of Aged Rhesus Monkeys Treated with MPTP

@article{Huang2018PhosphorylatedA,
  title={Phosphorylated $\alpha$-Synuclein Accumulations and Lewy Body-like Pathology Distributed in Parkinson’s Disease-Related Brain Areas of Aged Rhesus Monkeys Treated with MPTP},
  author={Baihui Huang and Shi-Hao Wu and Zhengbo Wang and Longjiao Ge and Joshua Dominic Rizak and Jing Wu and Jiali Li and Lin Xu and Longbao Lv and Yong Yin and Xintian Hu and Hao Li},
  journal={Neuroscience},
  year={2018},
  volume={379},
  pages={302-315}
}
Phosphorylation of α-synuclein at serine 129 (P-Ser 129 α-syn) is involved in the pathogenesis of Parkinson's disease (PD) and Lewy body (LB) formation. However, there is no clear evidence indicates the quantitative relation of P-Ser 129 α-syn accumulation and dopaminergic cell loss, LBs pathology and the affected brain areas in PD monkeys. Here, pathological changes in the substantia nigra (SN) and PD-related brain areas were measured in aged monkeys treated with 1-methyl-4-phenyl-1,2,3,6… Expand
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