Phosphoryl Transfer and Calcium Ion Occlusion in the Calcium Pump

@article{Srensen2004PhosphorylTA,
  title={Phosphoryl Transfer and Calcium Ion Occlusion in the Calcium Pump},
  author={Thomas Lykke-M{\o}ller S{\o}rensen and Jesper Vuust M{\o}ller and Poul Nissen},
  journal={Science},
  year={2004},
  volume={304},
  pages={1672 - 1675}
}
A tight coupling between adenosine triphosphate (ATP) hydrolysis and vectorial ion transport has to be maintained by ATP-consuming ion pumps. We report two crystal structures of Ca2+-bound sarco(endo)plasmic reticulum Ca2+–adenosine triphosphatase (SERCA) at 2.6 and 2.9 angstrom resolution in complex with (i) a nonhydrolyzable ATP analog [adenosine (β–γ methylene)–triphosphate] and (ii) adenosine diphosphate plus aluminum fluoride. SERCA reacts with ATP by an associative mechanism mediated by… 
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