Phosphorus nuclear magnetic resonance of perfused working rat hearts

@article{Jacobus1977PhosphorusNM,
  title={Phosphorus nuclear magnetic resonance of perfused working rat hearts},
  author={W E Jacobus and G. Jeffrey Taylor and Donald P. Hollis and Ray L Nunnally},
  journal={Nature},
  year={1977},
  volume={265},
  pages={756-758}
}
THERE are serious limitations to techniques used to correlate biochemical parameters with function in metabolically active tissues. For the perfused heart such techniques include measurement of surface NADH fluorescence2, comparison of coronary arterial–venous composition, and biochemical analysis of intracellular metabolites from biopsy specimens. Although the latter approach has yielded critical information, it is limited because local injury prevents accurate interpretation of mechanical… CONTINUE READING

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