Phosphorothioate DNA as an antioxidant in bacteria

@inproceedings{Xie2012PhosphorothioateDA,
  title={Phosphorothioate DNA as an antioxidant in bacteria},
  author={Xinqiang Xie and Jingdan Liang and Tianning Pu and Fei Xu and Fen Xia Yao and Yan Yang and Yi-Lei Zhao and Delin You and Xiufen Zhou and Zixin Deng and Zhijun Wang},
  booktitle={Nucleic acids research},
  year={2012}
}
Diverse bacteria contain DNA with sulfur incorporated stereo-specifically into their DNA backbone at specific sequences (phosphorothioation). We found that in vitro oxidation of phosphorothioate (PT) DNA by hydrogen peroxide (H(2)O(2)) or peracetic acid has two possible outcomes: DNA backbone cleavage or sulfur removal resulting in restoration of normal DNA backbone. The physiological relevance of this redox reaction was investigated by challenging PT DNA hosting Salmonella enterica cells using… CONTINUE READING

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