Phosphorolytic error correction during transcription.


Escherichia coli DNA-directed RNA polymerase is shown to contain a novel phosphorolytic error correction activity which removes erroneous nucleotides, as rNDPs, from the 3'-end of the growing transcript. The activity we describe is biochemically similar to polynucleotide phosphorylase (PNP), yet in contrast to PNP is activated by Mn2+. We demonstrate that… (More)


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@article{Libby1994PhosphorolyticEC, title={Phosphorolytic error correction during transcription.}, author={Richard T Libby and Jonathan Gallant}, journal={Molecular microbiology}, year={1994}, volume={12 1}, pages={121-9} }