Phosphoribosyltransferase Fusion Gene Transfer of a Bifunctional Yeast Cytosine Deaminase/Uracil Cancer Gene Therapy by Adenovirus-mediated In Vivo


Direct transfer of prodrug activation systems into tumors was demonstrated to be an attractive method for the selective in vivo elimination of tumor cells. However, most current suicide gene therapy strategies are still handicapped by a poor efficiency of in vivo gene transfer and a limited bystander cell killing effect. In this study, we describe a novel… (More)


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