Phosphoribosylpyrophosphate synthetase (PRS): a new gene family in Saccharomyces cerevisiae.

  title={Phosphoribosylpyrophosphate synthetase (PRS): a new gene family in Saccharomyces cerevisiae.},
  author={Andrew T. Carter and Arjan Narbad and Bruce M. Pearson and Konstanze Beck and Marc Logghe and Roland Contreras and Michael Schweizer},
  volume={10 8},
Saccharomyces cerevisiae contains at least four PRS genes, all of which have been cloned and sequenced. Each of the four derived amino acid sequences have more than 60% similarity to the corresponding polypeptides of man, rat, Escherichia coli and Salmonella typhimurium. The PRS1 gene maps on chromosome XI, PRS2 on chromosome V, PRS3 on chromosome VIII and PRS4 on chromosome II. One member of this gene family, PRS1, contains a region of non-homology (NHR) shown by cDNA cloning and sequencing… CONTINUE READING