Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance.

@article{HoveJensen2017PhosphoribosylD,
  title={Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance.},
  author={Bjarne Hove-Jensen and Kasper R. Andersen and Mogens Kilstrup and Jan Martinussen and Robert L. Switzer and Martin Willemo{\"e}s},
  journal={Microbiology and molecular biology reviews : MMBR},
  year={2017},
  volume={81 1}
}
Phosphoribosyl diphosphate (PRPP) is an important intermediate in cellular metabolism. PRPP is synthesized by PRPP synthase, as follows: ribose 5-phosphate + ATP → PRPP + AMP. PRPP is ubiquitously found in living organisms and is used in substitution reactions with the formation of glycosidic bonds. PRPP is utilized in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, the cofactors NAD and tetrahydromethanopterin, arabinosyl monophosphodecaprenol… CONTINUE READING

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