Phosphoregulation of Arp2/3-dependent actin assembly during receptor-mediated endocytosis

  title={Phosphoregulation of Arp2/3-dependent actin assembly during receptor-mediated endocytosis},
  author={Jiro Toshima and Adam C. Martin and David G Drubin},
  journal={Nature Cell Biology},
In both yeast and mammals, endocytic internalization is accompanied by a transient burst of actin polymerization. The yeast protein kinases Prk1p and Ark1p, which are related to the mammalian proteins GAK and AAK1, are key regulators of this process. However, the molecular mechanism(s) by which they regulate actin assembly at endocytic sites have not yet been determined. The Eps15-like yeast protein Pan1p is a Prk1p substrate that is essential for endocytic internalization and for proper actin… CONTINUE READING

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