Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

  title={Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion},
  author={M. Alam and Lev Solyakov and A. Bottrill and Christian Flueck and Faiza Amber Siddiqui and S. Singh and S. Mistry and Maria Viskaduraki and Kate D. Lee and Christine S. Hopp and C. Chitnis and C. Doerig and R. Moon and J. Green and A. Holder and D. Baker and A. Tobin},
  journal={Nature Communications},
  • M. Alam, Lev Solyakov, +14 authors A. Tobin
  • Published 2015
  • Biology, Medicine
  • Nature Communications
  • Our understanding of the key phosphorylation-dependent signalling pathways in the human malaria parasite, Plasmodium falciparum, remains rudimentary. Here we address this issue for the essential cGMP-dependent protein kinase, PfPKG. By employing chemical and genetic tools in combination with quantitative global phosphoproteomics, we identify the phosphorylation sites on 69 proteins that are direct or indirect cellular targets for PfPKG. These PfPKG targets include proteins involved in cell… CONTINUE READING
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