Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure.

@article{Shinoda2015PhosphoproteomicsIC,
  title={Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure.},
  author={Kosaku Shinoda and Kana Ohyama and Yutaka Hasegawa and Hsin-Yi Chang and Mayu Ogura and Atsushi Sato and Haemin Hong and Takashi Hosono and Louis Z. Sharp and David W. Scheel and Mark J. Graham and Yasushi Ishihama and Shingo Kajimura},
  journal={Cell metabolism},
  year={2015},
  volume={22 6},
  pages={
          997-1008
        }
}
Catecholamines promote lipolysis both in brown and white adipocytes, whereas the same stimuli preferentially activate thermogenesis in brown adipocytes. Molecular mechanisms for the adipose-selective activation of thermogenesis remain poorly understood. Here, we employed quantitative phosphoproteomics to map global and temporal phosphorylation profiles in brown, beige, and white adipocytes under β3-adrenenoceptor activation and identified kinases responsible for the adipose-selective… CONTINUE READING
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Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure, Cell Metabolism

  • Shinoda
  • 2015

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