Phosphoproteomic biomarkers predicting histologic nonalcoholic steatohepatitis and fibrosis.

  title={Phosphoproteomic biomarkers predicting histologic nonalcoholic steatohepatitis and fibrosis.},
  author={Zobair M Younossi and Ancha V. Baranova and Maria Stepanova and Sandra J. Page and Valerie S. Calvert and Arian Afendy and Zachary D. Goodman and Vikas Chandhoke and Lance A. Liotta and Emanual F. Petricoin},
  journal={Journal of proteome research},
  volume={9 6},
The progression of nonalcoholic fatty liver disease (NAFLD) has been linked to deregulated exchange of the endocrine signaling between adipose and liver tissue. Proteomic assays for the phosphorylation events that characterize the activated or deactivated state of the kinase-driven signaling cascades in visceral adipose tissue (VAT) could shed light on the pathogenesis of nonalcoholic steatohepatitis (NASH) and related fibrosis. Reverse-phase protein microarrays (RPMA) were used to develop… CONTINUE READING
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