Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration.

@article{Herskowitz2010PhosphoproteomicAR,
  title={Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration.},
  author={Jeremy H Herskowitz and Nicholas T Seyfried and Duc M Duong and Qiangwei Xia and Howard D. Rees and Marla Gearing and Junmin Peng and James J Lah and Allan I. Levey},
  journal={Journal of proteome research},
  year={2010},
  volume={9 12},
  pages={6368-79}
}
Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disease characterized by behavioral abnormalities, personality changes, language dysfunction, and can co-occur with the development of motor neuron disease. One major pathological form of FTLD is characterized by intracellular deposition of ubiquitinated and phosphorylated TAR DNA binding protein-43 (TDP-43), suggesting that dysregulation in phosphorylation events may contribute to disease progression. However, to date… CONTINUE READING