Phosphoproteomic analysis of human embryonic stem cells.

  title={Phosphoproteomic analysis of human embryonic stem cells.},
  author={Laurence M. Brill and Wen Xiong and K. Lee and Scott B. Ficarro and Andrew Downer Crain and Yue Xu and Alexey Terskikh and Evan Yale Snyder and Sheng Ding},
  journal={Cell stem cell},
  volume={5 2},
Protein phosphorylation, while critical to cellular behavior, has been undercharacterized in pluripotent cells. Therefore, we performed phosphoproteomic analyses of human embryonic stem cells (hESCs) and their differentiated derivatives. A total of 2546 phosphorylation sites were identified on 1602 phosphoproteins; 389 proteins contained more phosphorylation site identifications in undifferentiated hESCs, whereas 540 contained more such identifications in differentiated derivatives… CONTINUE READING
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Analysis of protein phosphorylation using mass spectrometry: deciphering the phosphoproteome

  • M. Mann, S. E. Ong, M. Gronborg, H. Steen, O. N. Jensen, A. Pandey
  • Trends Biotechnol
  • 2002
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