Phosphoproteomic analysis identifies proteins involved in transcription-coupled mRNA decay as targets of Snf1 signaling

@article{Braun2014PhosphoproteomicAI,
  title={Phosphoproteomic analysis identifies proteins involved in transcription-coupled mRNA decay as targets of Snf1 signaling},
  author={Katherine A. Braun and Stefania Vaga and Kenneth M. Dombek and Fang Fang and Salvator Palmisano and Ruedi Aebersold and Elton T. Young},
  journal={Science Signaling},
  year={2014},
  volume={7},
  pages={ra64-ra64}
}
Stresses, such as glucose depletion, activate Snf1, the Saccharomyces cerevisiae ortholog of adenosine monophosphate–activated protein kinase (AMPK), enabling adaptive cellular responses. In addition to affecting transcription, Snf1 may also promote mRNA stability in a gene-specific manner. To understand Snf1-mediated signaling, we used quantitative mass spectrometry to identify proteins that were phosphorylated in a Snf1-dependent manner. We identified 210 Snf1-dependent phosphopeptides in 145… CONTINUE READING
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