Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1)

@inproceedings{Demirkan2011PhosphoproteomicPO,
  title={Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1)},
  author={Gokhan Demirkan and Kebing Yu and Joan M. Boylan and Arthur R. Salomon and Philip A Gruppuso},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Our understanding of signal transduction networks in the physiological context of an organism remains limited, partly due to the technical challenge of identifying serine/threonine phosphorylated peptides from complex tissue samples. In the present study, we focused on signaling through the mammalian target of rapamycin (mTOR) complex 1 (mTORC1), which is at the center of a nutrient- and growth factor-responsive cell signaling network. Though studied extensively, the mechanisms… CONTINUE READING