Phosphoproteome analysis of the MAPK pathway reveals previously undetected feedback mechanisms.

Abstract

The RAS-RAF-MEK-ERK (MAPK) pathway is prevalently perturbed in cancer. Recent large-scale sequencing initiatives profiled thousands of tumors providing insight into alterations at the DNA and RNA levels. These efforts confirmed that key nodes of the MAPK pathway, in particular KRAS and BRAF, are among the most frequently altered proteins in cancer. The… (More)
DOI: 10.1002/pmic.201600119

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