Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro.

@article{BirkenkampDemtroder2007PhosphoproteinK2,
  title={Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro.},
  author={Karin Birkenkamp-Demtroder and Francisco Mansilla and Flemming Brandt S\orensen and Mogens Kruh\offer and Teresa Cabez{\'o}n and Lise Lotte Christensen and Lauri A. Aaltonen and Hein W. Verspaget and Torben F. \Orntoft},
  journal={Molecular oncology},
  year={2007},
  volume={1 2},
  pages={181-95}
}
Transcript profiling of 27 normal colon mucosas and 258 adenocarcinomas showed Keratin23 to be increased in 78% microsatellite-stable tumors, while microsatellite-instable tumors showed low transcript levels, comparable to normal mucosas. Immunohistochemical analyses demonstrated that 88% of microsatellite-instable tumors were negative for Keratin23 protein, while 70% of MSS tumors and metastases derived from MSS-tumors showed high Keratin23 levels. Immunofluorescence analysis localized… CONTINUE READING