Phosphonate derivatives of tetraazamacrocycles as new inhibitors of protein tyrosine phosphatases.

Abstract

α,α-Difluoro-β-ketophosphonated derivatives of tetraazamacrocycles were synthesized and found to be potential inhibitors of protein tyrosine phosphatases. N-Substituted conjugates of cyclam and cyclen with bioisosteric phosphonate groups displayed good activities toward T-cell protein tyrosine phosphatase with IC50 values in the micromolar to nanomolar… (More)
DOI: 10.1039/c5ob00713e

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