Phosphomannosyl-enzyme receptors in rat liver. Subcellular distribution and role in intracellular transport of lysosomal enzymes.

@article{Fischer1980PhosphomannosylenzymeRI,
  title={Phosphomannosyl-enzyme receptors in rat liver. Subcellular distribution and role in intracellular transport of lysosomal enzymes.},
  author={H. D. Fischer and Alfonso Gonz{\'a}lez-Noriega and William S. Sly and Dorothy M. Morr{\'e}},
  journal={The Journal of biological chemistry},
  year={1980},
  volume={255 20},
  pages={9608-15}
}
beta-Hexosaminidase B purified from human fibroblast secretions was used as a ligand to study phosphomannosyl-enzyme receptors in membranes from rat tissues. Enzyme binding to rat liver membranes was saturable, competitively inhibited by mannose 6-phosphate, not dependent on calcium, and destroyed by prior treatment of the hexosaminidase with either alkaline phosphatase or endoglycosidase H. Most (90%) of the phosphomannosyl-enzyme receptors were found in endoplasmic reticulum, Golgi apparatus… CONTINUE READING
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