Phospholipids that contain polyunsaturated fatty acids enhance neuronal cell mechanics and touch sensation.

@article{Vsquez2014PhospholipidsTC,
  title={Phospholipids that contain polyunsaturated fatty acids enhance neuronal cell mechanics and touch sensation.},
  author={Valeria V{\'a}squez and Michael Krieg and Dean Lockhead and Miriam B Goodman},
  journal={Cell reports},
  year={2014},
  volume={6 1},
  pages={70-80}
}
Mechanoelectrical transduction (MeT) channels embedded in neuronal cell membranes are essential for touch and proprioception. Little is understood about the interplay between native MeT channels and membrane phospholipids, in part because few techniques are available for altering plasma membrane composition in vivo. Here, we leverage genetic dissection, chemical complementation, and optogenetics to establish that arachidonic acid (AA), an omega-6 polyunsaturated fatty acid, enhances touch… CONTINUE READING
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