Phospholipids regulate localization and activity of mDia1 formin.

  title={Phospholipids regulate localization and activity of mDia1 formin.},
  author={Nagendran Ramalingam and Hongxia Zhao and Dennis Breitsprecher and Pekka Lappalainen and Jan Faix and Michael Schleicher},
  journal={European journal of cell biology},
  volume={89 10},
Diaphanous-related formins (DRFs) are large multi-domain proteins that nucleate and assemble linear actin filaments. Binding of active Rho family proteins to the GTPase-binding domain (GBD) triggers localization at the membrane and the activation of most formins if not all. In recent years GTPase regulation of formins has been extensively studied, but other molecular mechanisms that determine subcellular distribution or regulate formin activity have remained poorly understood. Here, we provide… CONTINUE READING