Phospholipid transfer protein is regulated by liver X receptors in vivo.

  title={Phospholipid transfer protein is regulated by liver X receptors in vivo.},
  author={Guoqing Cao and Thomas P. Beyer and Xiao Ping Yang and Robert J. Schmidt and Youyan Zhang and William R. Bensch and Raymond F. Kauffman and Hong Gao and Timothy P. Ryan and Yu Liang and Patrick I. Eacho and Xian-cheng Jiang},
  journal={The Journal of biological chemistry},
  volume={277 42},
Liver X receptors (LXR) belong to the nuclear receptor superfamily that can regulate important lipid metabolic pathways. The plasma phospholipid transfer protein (PLTP) is known to mediate transfer of phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL) and plays a critical role in HDL metabolism. We report here that a specific LXR agonist, T0901317, elevated HDL cholesterol and phospholipid in C57/BL6 mice and generated enlarged HDL particles that were enriched… CONTINUE READING