Phospholipid transfer protein deficiency impairs apolipoprotein-B secretion from hepatocytes by stimulating a proteolytic pathway through a relative deficiency of vitamin E and an increase in intracellular oxidants.

@article{Jiang2005PhospholipidTP,
  title={Phospholipid transfer protein deficiency impairs apolipoprotein-B secretion from hepatocytes by stimulating a proteolytic pathway through a relative deficiency of vitamin E and an increase in intracellular oxidants.},
  author={Xian-cheng Jiang and Zhiqiang Li and Ruijie Liu and Xiao Ping Yang and Meihui Pan and Laurent Lagrost and Edward A Fisher and Kevin J. Williams},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 18},
  pages={18336-40}
}
Genetic deficiency of the plasma phospholipid transfer protein (PLTP) in mice unexpectedly causes a substantial impairment in liver secretion of apolipoprotein-B (apoB), the major protein of atherogenic lipoproteins. To explore the mechanism, we examined the three known pathways for hepatic apoB secretory control, namely endoplasmic reticulum (ER)/proteasome-associated degradation (ERAD), post-ER pre-secretory proteolysis (PERPP), and receptor-mediated degradation, also known as re-uptake… CONTINUE READING
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