Phospholipid transfer protein and alpha-1 antitrypsin regulate Hck kinase activity during neutrophil degranulation

@article{Ochieng2018PhospholipidTP,
  title={Phospholipid transfer protein and alpha-1 antitrypsin regulate Hck kinase activity during neutrophil degranulation},
  author={Pius O. Ochieng and Sridesh Nath and Reane Macarulay and Edward Eden and Abdoulaye J. Dabo and Michael A Campos and Xian-cheng Jiang and Robert F. Foronjy and Patrick Geraghty},
  journal={Scientific Reports},
  year={2018},
  volume={8}
}
Excessive neutrophil degranulation is a common feature of many inflammatory disorders, including alpha-1 antitrypsin (AAT) deficiency. Our group has demonstrated that phospholipid transfer protein (PLTP) prevents neutrophil degranulation but serine proteases, which AAT inhibits, cleave PLTP in diseased airways. We propose to identify if airway PLTP activity can be restored by AAT augmentation therapy and how PLTP subdues degranulation of neutrophils in AAT deficient subjects. Airway PLTP… 
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