Phospholipid transfer protein (PLTP) deficiency reduces brain vitamin E content and increases anxiety in mice.

@article{Desrumaux2005PhospholipidTP,
  title={Phospholipid transfer protein (PLTP) deficiency reduces brain vitamin E content and increases anxiety in mice.},
  author={Catherine M Desrumaux and P Y Risold and Henri Schroeder and Val{\'e}rie Deckert and David R. Masson and Anne Athias and H{\'e}l{\`e}ne Laplanche and Naig Le Guern and Denis Blache and Xian-cheng Jiang and Alan Richard Tall and Didier Desor and Laurent Lagrost},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2005},
  volume={19 2},
  pages={296-7}
}
Vitamin E supplementation constitutes a promising strategy in the prevention of neurodegenerative diseases. Here, we show that a phospholipid transfer protein (PLTP) is widely expressed in the brain where it appears to function as a transfer factor for alpha-tocopherol, the main isomer of vitamin E. PLTP deficiency results in significant depletion of brain alpha-tocopherol in both homozygous (-30.1%, P<0.0002) and heterozygous (-18.0%, P<0.05) PLTP knocked-out mice. Alpha-tocopherol depletion… CONTINUE READING

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