Phospholipid spectrum and lipid peroxidation in cell membranes of brain tissue in thymectomized rats

Abstract

Lipid peroxidation (LPO) processes and the phospholipid (PL) content and composition in the homogenate and in the mitochondrial and supramitochondrial compartments of brain cells of adult male rats were studied 3 and 6 months after thymectomy. Thymectomy was found to markedly increase the rate of LPO and to reduce antiradical activity in all cellular compartments. A reliable increase of the level of total phospholipids in the homogenate and mitochondria was observed by the third month after thymectomy and a reduction of its control levels during the sixth month postoperation. On the other hand, a reduction of the content of total phospholipids was observed in the supramitochondrial fraction by the sixth month of the experiment. An increase of the phosphatidylethanolamine (PE) and phosphatidylserine (PS) contents was found to be mainly responsible for the changes in the level of total phospholipids.

DOI: 10.1007/BF02444361

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Cite this paper

@article{Serebrov2006PhospholipidSA, title={Phospholipid spectrum and lipid peroxidation in cell membranes of brain tissue in thymectomized rats}, author={Vladimir Serebrov and O. A. Timin}, journal={Bulletin of Experimental Biology and Medicine}, year={2006}, volume={118}, pages={701-703} }