Phospholipid scramblase 3 is the mitochondrial target of protein kinase C delta-induced apoptosis.

@article{Liu2003PhospholipidS3,
  title={Phospholipid scramblase 3 is the mitochondrial target of protein kinase C delta-induced apoptosis.},
  author={Jihua Liu and Jun Chen and Qiang Dai and Ray M. Lee},
  journal={Cancer research},
  year={2003},
  volume={63 6},
  pages={1153-6}
}
Protein kinase C (PKC) delta translocates to mitochondria during apo-ptosis,but its mitochondrial target remains unclear. We found that PKC-delta physically interacted with and phosphorylated phospholipid scramblase 3 (PLS3) after UV irradiation. PLS3 is a high-affinity substrate for PKC-delta in vitro with the K(m) at 10.5 nM. Cells expressing wild-type PLS3 became apoptotic on phorbol ester stimulation, whereas the control cells did not. Expression of a mitochondrial-targeted PKC-delta… CONTINUE READING