Phospholipid scramblase: An update

  title={Phospholipid scramblase: An update},
  author={E. Bevers and P. Williamson},
  journal={FEBS Letters},
  • E. Bevers, P. Williamson
  • Published 2010
  • Medicine, Biology
  • FEBS Letters
  • The best understood consequence of the collapse of lipid asymmetry is exposure of phosphatidylserine (PS) in the external leaflet of the plasma membrane bilayer, where it is known to serve at least two major functions: providing a platform for development of the blood coagulation cascade and presenting the signal that induces phagocytosis of apoptotic cells. Lipid asymmetry is collapsed by activation of phospholipid scramblase(s) that catalyze bidirectional transbilayer movement of the major… CONTINUE READING

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