Phospholipid metabolism of stimulated lymphocytes. Composition of phospholipid fatty acids.

  title={Phospholipid metabolism of stimulated lymphocytes. Composition of phospholipid fatty acids.},
  author={Ernst Ferber and Giuseppe De Pasquale and K. Resch},
  journal={Biochimica et biophysica acta},
  volume={398 3},
Incorporation of fatty acids by concanavalin A-stimulated lymphocytes and the effect on fatty acid composition and membrane fluidity.
It is proposed that the changes in lymphocyte phospholipid fatty acid composition and membrane fluidity brought about by culture in the presence of polyunsaturated fatty acids are responsible for the inhibition of lymphocyte functions caused by these fatty acids.
Fatty acid positional specificity in phospholipids of L1210 leukemia and normal mouse lymphocytes
The positional distribution of fatty acids in the choline and ethanolamine phosphoglycerides of the L1210 murine leukemia cells was determined and compared to that of normal mouse lymphocytes to demonstrate that fatty acid positional specificity is retained in the major phospholipids of this rapidly growing tumor.
Changes in the Incorporation of Free Fatty Acids Upon the Stimulation of Human Polymorphonuclear Leukocytes
Stimulation of PMN with serum‐treated zymosan or the chemotactic peptide f‐met‐leu‐phe but not phorbol myristate acetate increased the incorporation of fatty acids into these phospholipids, and stimulation‐induced incorporation of fats was directed exlusively into position 2 of the lipid.
Composition and metabolism of fatty acids in phospholipids of density-separated red cells of rats
Fatty acid compositions of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) and the rates of fatty acid esterification to these phospholipids (PL) were measured in intact rat red cell


Phospholipid Metabolism of Stimulated Lymphocytes
The relevance of the observed rapid changes in the membrane phospholipids for the mechanisms of lymphocyte activation is discussed.
Lymphocyte activation: Rapid changes in the phospholipid metabolism of plasma membranes during stimulation
Lymph node lymphocytes from normal or BCG‐sensitized rabbits were stimulated by phytohemagglutinin (PHA) or purified protein derivative of tuberculin ( PPD) and microsomes (consisting of plasma membrane and endoplasmic reticulum) were isolated.
Structural studies of neutral glycerides and phosphoglycerides of rat liver.
Lipid class and fatty acid composition of rat liver plasma membranes isolated by zonal centrifugation.
The plasma membranes of rat liver isolated by zonal centrifugation appear to have many features of lipid composition similar to those reported by others for pure membranes ofrat erythrocytes, and the fatty acid composition of the mixture of phosphatidic acid and polyglycerolphosphatides was similar to that ofosphatidylcholine and phosphatIDylethanolamine.
Characterization and quantification of red cell lipids in normal man.
Human red cell lipids have been studied in a series of normal individuals and evidence is presented that the total amount of lipid phosphorus per average red cell is 1.40 X lo-" mg and that most extraction procedures fail to extract 870 or more of red cell phospholipid.
Isolation and characterization of lymphocyte plasma membranes.
Structural and metabolic heterogeneity of rat liver glycerophosphatides.
  • G. Arvidson
  • Biology, Chemistry
    European journal of biochemistry
  • 1968
In fasting male and female rats the tetraunsaturated or arachidonoyl-containing subfraction was found to be of quantitative dominance in both phosphatidylcholines and phosphatIDylethanolamines, whereas the latter contained relatively more of the hexaunsaturated fraction than the phosphorus-based subfractions.