Phospholipid-mediated delivery of anti-GAP-43 antibodies into neuroblastoma cells prevents neuritogenesis.

  title={Phospholipid-mediated delivery of anti-GAP-43 antibodies into neuroblastoma cells prevents neuritogenesis.},
  author={Thomas B. Shea and Nora I. Perrone-Bizzozero and Mary Lou Beermann and Larry Benowitz},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={11 6},
The neuronal growth-associated protein GAP-43 is expressed during axonal outgrowth and regeneration (for review, see Benowitz and Routtenberg, 1987). In the present study, we demonstrate that GAP-43 is constitutively expressed by NB2a/d1 neuroblastoma cells. The initial, most rapid outgrowth period of neuritogenesis [0-4 hr after dibutyryl adenosine 3',5'-cyclic monophosphate (dbcAMP) treatment] is accompanied by intense GAP-43 immunoreactivity along the entire length of most neurites. However… CONTINUE READING
31 Citations
33 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 31 extracted citations


Publications referenced by this paper.
Showing 1-10 of 33 references

GAP-43 expression without neurite extension

  • JT Megerian, JP Sullivan, WL Klein
  • Sot Neurosci Abstr
  • 1989
Highly Influential
4 Excerpts

The nattem of GAP43 immunostaini~g changes in the rat hippocampal formation during reactive synaptogenesis

  • WR Rodrieuez, RL Neve
  • Mol Brain Res
  • 1990

Similar Papers

Loading similar papers…