Phospholipid-dependent regulation of the motor activity of myosin X

  title={Phospholipid-dependent regulation of the motor activity of myosin X},
  author={Nobuhisa Umeki and Hyun Suk Jung and Tsuyoshi Sakai and Osamu Sato and Reiko Ikebe and Mitsuo Ikebe},
  journal={Nature Structural \&Molecular Biology},
Myosin X is involved in the reorganization of the actin cytoskeleton and protrusion of filopodia. Here we studied the molecular mechanism by which bovine myosin X is regulated. The globular tail domain inhibited the motor activity of myosin X in a Ca2+-independent manner. Structural analysis revealed that myosin X is monomeric and that the band 4.1-ezrin-radixin-moesin (FERM) and pleckstrin homology (PH) domains bind to the head intramolecularly, forming an inhibited conformation. Binding of… 

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