Phospholipid conjugate for intracellular delivery of peptide nucleic acids.

Abstract

Peptide nucleic acids (PNAs) have a number of attractive features that have made them an ideal choice for antisense and antigene-based tools, probes, and drugs, but their poor membrane permeability has limited their application as therapeutic or diagnostic agents. Herein, we report a general method for the synthesis of phospholipid-PNAs (LP-PNAs) and… (More)
DOI: 10.1021/bc900048y

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