Phospholipid catalysis of diabetic amyloid assembly.

  title={Phospholipid catalysis of diabetic amyloid assembly.},
  author={Jefferson D Knight and Andrew D Miranker},
  journal={Journal of molecular biology},
  volume={341 5},
Islet amyloid polypeptide (IAPP) is a 37-residue hormone that forms cytotoxic amyloid fibers in the endocrine pancreas of patients with type II diabetes (NIDDM). A potential origin for cytotoxicity is disruption of lipid membranes by IAPP as has been observed in vitro. The cause of amyloid formation during NIDDM is not known, nor is the mechanism by which membrane disruption occurs in vitro. Here, we use kinetic studies in conjunction with assessments of lipid binding and electron microscopy to… CONTINUE READING