Phospholipid association reduces the gastric mucosal toxicity of aspirin in human subjects

@article{Anand1999PhospholipidAR,
  title={Phospholipid association reduces the gastric mucosal toxicity of aspirin in human subjects},
  author={Bhupinderjit S. Anand and Jim J. Romero and Sudershan K Sanduja and Lenard M. Lichtenberger},
  journal={American Journal of Gastroenterology},
  year={1999},
  volume={94},
  pages={1818-1822}
}
OBJECTIVES:In previous studies on rats, we have shown that aspirin (ASA)-induced injury to the gastric mucosa is markedly reduced or completely abolished if ASA is chemically associated with the phospholipid, phosphatidylcholine (PC). We have also shown that the protective effect of PC does not influence the ability of ASA to inhibit mucosal cyclooxygenase (COX) activity in the stomach and other tissues. We therefore sought to assess the effect of PC-associated ASA (ASA/PC) on the gastric… CONTINUE READING

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The antral mucosal COX activity , as well as the level of prostaglandin 6-keto PGF1α , were reduced significantly ( 80–88% ) and to a similar extent by both ASA and ASA / PC.CONCLUSIONS : The present study shows that acute aspirin - induced damage to the gastric mucosa can be reduced by chemically associating ASA with PC .
The antral mucosal COX activity , as well as the level of prostaglandin 6-keto PGF1α , were reduced significantly ( 80–88% ) and to a similar extent by both ASA and ASA / PC.CONCLUSIONS : The present study shows that acute aspirin - induced damage to the gastric mucosa can be reduced by chemically associating ASA with PC .
The antral mucosal COX activity , as well as the level of prostaglandin 6-keto PGF1α , were reduced significantly ( 80–88% ) and to a similar extent by both ASA and ASA / PC.CONCLUSIONS : The present study shows that acute aspirin - induced damage to the gastric mucosa can be reduced by chemically associating ASA with PC .
We have also shown that the protective effect of PC does not influence the ability of ASA to inhibit mucosal cyclooxygenase ( COX ) activity in the stomach and other tissues .
OBJECTIVES : In previous studies on rats , we have shown that aspirin ( ASA)-induced injury to the gastric mucosa is markedly reduced or completely abolished if ASA is chemically associated with the phospholipid , phosphatidylcholine ( PC ) .
OBJECTIVES : In previous studies on rats , we have shown that aspirin ( ASA)-induced injury to the gastric mucosa is markedly reduced or completely abolished if ASA is chemically associated with the phospholipid , phosphatidylcholine ( PC ) .
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