Phospholipid Alterations in Hepatocyte Membranes and Transporter Protein Changes in Cholestatic Rat Model

@article{Hyogo2001PhospholipidAI,
  title={Phospholipid Alterations in Hepatocyte Membranes and Transporter Protein Changes in Cholestatic Rat Model},
  author={Hideyuki Hyogo and Susumu Tazuma and Tomoji Nishioka and Hidenori Ochi and Atushi Yamaguchi and Yoshihiro Numata and Keishi Kanno and Minoru Sakomoto and Yasumasa Asamoto and Kazuhiko Tsuboi and Kuniharu Nakai and Shigeyuki Yasumiba and Yasushi Sunami and Goro Kajiyama},
  journal={Digestive Diseases and Sciences},
  year={2001},
  volume={46},
  pages={2089-2097}
}
Biliary components are transported by hepatic adenosine triphosphate-binding cassette (ABC) transporters that are located in canalicular membranes. Physiological transporter function is related to membrane fluidity, which is modulated by the phospholipid composition of the lipid bilayer. We hypothesized that cholestasis may alter transporter function by modifying phospholipid species to protect the cell from cholestatic damage. Therefore, we examined the expression of ABC transport proteins and… CONTINUE READING