Phospholipase PlaB is a new virulence factor of Legionella pneumophila.

@article{Schunder2010PhospholipasePI,
  title={Phospholipase PlaB is a new virulence factor of Legionella pneumophila.},
  author={Eva Schunder and Patrick Adam and Futoshi Higa and Katharina A. Remer and Udo Lorenz and Jennifer C. Bender and Tino Schulz and Antje Flieger and Michael Steinert and Klaus Heuner},
  journal={International journal of medical microbiology : IJMM},
  year={2010},
  volume={300 5},
  pages={
          313-23
        }
}
We previously identified Legionella pneumophila PlaB as the major cell-associated phospholipase A/lysophospholipase A with contact-dependent hemolytic activity. In this study, we further characterized this protein and found it to be involved in the virulence of L. pneumophila. PlaB was mainly expressed and active during exponential growth. Active PlaB was outer membrane-associated and at least in parts surface-exposed. Transport to the outer membrane was not dependent on the type I (T1SS), II… CONTINUE READING
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