Phospholipase D2 functions as a downstream signaling molecule of MAP kinase pathway in L1-stimulated neurite outgrowth of cerebellar granule neurons.

@article{Watanabe2004PhospholipaseDF,
  title={Phospholipase D2 functions as a downstream signaling molecule of MAP kinase pathway in L1-stimulated neurite outgrowth of cerebellar granule neurons.},
  author={Hiroshi C Watanabe and Masakazu Yamazaki and Hideyuki Miyazaki and Chihiro Arikawa and Kouichi Itoh and Takehiko Sasaki and Tomohiko Maehama and Michael A. Frohman and Yasunori Kanaho},
  journal={Journal of neurochemistry},
  year={2004},
  volume={89 1},
  pages={142-51}
}
Stimulation of the neuronal cell adhesion molecule L1 in cerebellar granule neurons (CGNs) enhances neurite outgrowth and this response is inhibited by the primary alcohol ethanol. Because primary alcohols suppress the formation of the signaling lipid phosphatidic acid (PA) by phospholipase D (PLD), this observation prompted us to investigate whether PLD… CONTINUE READING