Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane.

@article{Mor2009PhospholipaseDR,
  title={Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane.},
  author={Adam Mor and Joseph P. Wynne and Ian Ahearn and Michael L. Dustin and Guangwei Du and Mark R Philips},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 12},
  pages={3297-306}
}
Rap1 is a small GTPase that modulates adhesion of T cells by regulating inside-out signaling through LFA-1. The bulk of Rap1 is expressed in a GDP-bound state on intracellular vesicles. Exocytosis of these vesicles delivers Rap1 to the plasma membrane, where it becomes activated. We report here that phospholipase D1 (PLD1) is expressed on the same vesicular compartment in T cells as Rap1 and is translocated to the plasma membrane along with Rap1. Moreover, PLD activity is required for both… CONTINUE READING

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