Phospholipase D structure and regulation.

  title={Phospholipase D structure and regulation.},
  author={Michael A. Frohman and Andrew J. Morris},
  journal={Chemistry and physics of lipids},
  volume={98 1-2},
The recent identification of cDNA clones for phospholipase D has opened the door to new types of investigations into its structure and regulation. PLD activity has been found to be encoded by at least two different genes that contain catalytic domains that relate their mechanism of action to phosphodiesterases. In vivo roles for PLD suggest that it may be important for multiples steps in regulated secretion and membrane biogenesis.