Phospholipase D-mTOR signaling is compromised in a rat model of depression.

@article{Feng2013PhospholipaseDS,
  title={Phospholipase D-mTOR signaling is compromised in a rat model of depression.},
  author={Pingfu Feng and Chunfa Huang},
  journal={Journal of psychiatric research},
  year={2013},
  volume={47 5},
  pages={579-85}
}
Depression is associated with structural and neurochemical changes in limbic structures, including the hippocampus, that control emotion and mood. Structural abnormalities such as decrease in hippocampal cell proliferation, neurogenesis and hippocampal volume, and loss of neurons and glial cells have been widely reported in physical and psychosocial stress paradigms and animal model of depression, but corresponding neurochemical changes are largely unknown. Using neonatal clomipramine (CL… CONTINUE READING
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