Phospholipase D and membrane traffic. Potential roles in regulated exocytosis, membrane delivery and vesicle budding.

@article{Jones1999PhospholipaseDA,
  title={Phospholipase D and membrane traffic. Potential roles in regulated exocytosis, membrane delivery and vesicle budding.},
  author={David A Jones and Councilman Morgan and Shamshad Cockcroft},
  journal={Biochimica et biophysica acta},
  year={1999},
  volume={1439 2},
  pages={229-44}
}
It is now well-established that phospholipase D is transiently stimulated upon activation by G-protein-coupled and receptor tyrosine kinase cell surface receptors in mammalian cells. Over the last 5 years, a tremendous effort has gone to identify the major intracellular regulators of mammalian phospholipase D and to the cloning of two mammalian phospholipase D enzymes (phospholipase D1 and D2). In this chapter, we review the physiological function of mammalian phospholipase D1 that is… CONTINUE READING