Phospholipase D and extracellular signal-regulated kinase in hepatic stellate cells: effects of platelet-derived growth factor and extracellular nucleotides.

@article{BentezRajal2006PhospholipaseDA,
  title={Phospholipase D and extracellular signal-regulated kinase in hepatic stellate cells: effects of platelet-derived growth factor and extracellular nucleotides.},
  author={Joaqu{\'i}n Ben{\'i}tez-Rajal and M. Lorite and A. Burt and C. Day and M. Thompson},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2006},
  volume={291 5},
  pages={
          G977-86
        }
}
We have previously provided evidence suggesting that phosphatidic acid, possibly derived from the hydrolysis of phosphatidylcholine by phospholipase D (PLD), is involved in platelet-derived growth factor (PDGF)-mediated increases in extracellular signal-regulated kinase (ERK) activity and DNA synthesis in rat hepatic stellate cells (HSC), the primary fibrogenic cells of the liver. A recent study has shown the presence of P2Y nucleotide receptors on HSC that are coupled to contraction and… Expand
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