Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells.

@article{Cummings2002PhospholipaseDA,
  title={Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells.},
  author={Rhett J Cummings and Narasimham L. Parinandi and Ari L. Zaiman and Lixin Wang and Peter V. Usatyuk and Joe G. N. Garcia and Viswanathan Natarajan},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 33},
  pages={30227-35}
}
Sphingosine 1-phosphate (S1P), a potent bioactive sphingolipid, has been implicated in many critical cellular events, including a regulatory role in the pathogenesis of airway inflammation. We investigated the participation of S1P as an inflammatory mediator by assessing interleukin-8 (IL-8) secretion and phospholipase D (PLD) activation in human bronchial epithelial cells (Beas-2B). S1P(1), S1P(3), S1P(4), S1P(5), and weak S1P(2) receptors were detected in Beas-2B and primary human bronchial… CONTINUE READING
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