Phospholipase Cbeta4 and protein kinase Calpha and/or protein kinase CbetaI are involved in the induction of long term depression in cerebellar Purkinje cells.

@article{Hirono2001PhospholipaseCA,
  title={Phospholipase Cbeta4 and protein kinase Calpha and/or protein kinase CbetaI are involved in the induction of long term depression in cerebellar Purkinje cells.},
  author={Moritoshi Hirono and Tomoyasu Sugiyama and Yasushi Kishimoto and Ikuko Sakai and Tatsuhiko Miyazawa and Masahiro Kishio and Hiroshi Numazu Inoue and Kazuwa Nakao and Mitsunobu Ikeda and Shigenori Kawahara and Yutaka. Kirino and Motoya Katsuki and Hidenori Horie and Yoshikazu Ishikawa and Takeo Yoshioka},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 48},
  pages={
          45236-42
        }
}
Activation of the type-1 metabotropic glutamate receptor (mGluR1) signaling pathway in the cerebellum involves activation of phospholipase C (PLC) and protein kinase C (PKC) for the induction of cerebellar long term depression (LTD). The PLC and PKC isoforms that are involved in LTD remain unclear, however. One previous study found no change in LTD in PKCgamma-deficient mice, thus, in the present study, we examined cerebellar LTD in PLCbeta4-deficient mice. Immunohistochemical and Western blot… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS

Transient receptor potential canonical channels regulate the induction of cerebellar long-term depression.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2012
VIEW 1 EXCERPT
CITES BACKGROUND

Similar Papers