Phospholipase Cbeta1b associates with a Shank3 complex at the cardiac sarcolemma.

@article{Grubb2011PhospholipaseCA,
  title={Phospholipase Cbeta1b associates with a Shank3 complex at the cardiac sarcolemma.},
  author={David R. Grubb and P. Iliades and Nicola Cooley and Yen Lin Yu and Jieting Luo and Theresa M. Filtz and Elizabeth A. Woodcock},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2011},
  volume={25 3},
  pages={1040-7}
}
Activation of the heterotrimeric G protein Gq causes cardiomyocyte hypertrophy in vivo and in cell models. Our previous studies have shown that responses to activated Gq in cardiomyocytes are mediated exclusively by phospholipase Cβ1b (PLCβ1b), because only this PLCβ subtype localizes at the cardiac sarcolemma. In the current study, we investigated the… CONTINUE READING