Phospholipase C in rabbit thymocytes: subcellular distribution and influences of calcium and GTP gamma S on the substrate dependence of cytosolic and plasma membrane-associated phospholipase C.

Abstract

The subcellular distribution of phospholipase C (PLC) activity in rabbit thymocytes was examined by measuring the enzyme's activity in different subcellular fractions. PLC activity was determined using exogenously added [3H]PIP2 as substrate. Approx. 80% of the activity of the cell homogenate was found in the cytosolic fraction. A minor portion of PLC… (More)

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@article{Behl1988PhospholipaseCI, title={Phospholipase C in rabbit thymocytes: subcellular distribution and influences of calcium and GTP gamma S on the substrate dependence of cytosolic and plasma membrane-associated phospholipase C.}, author={Benoy K. Behl and H Sommermeyer and Margarethe Goppelt-Struebe and Klaus Resch}, journal={Biochimica et biophysica acta}, year={1988}, volume={971 2}, pages={179-88} }