Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis.

@article{Xie2010PhospholipaseCI,
  title={Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis.},
  author={Zhongjian Xie and Yin Chen and Er-yuan Liao and Yi Jiang and Fu-you Liu and Sally D Pennypacker},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={397 2},
  pages={296-300}
}
The epidermal growth factor receptor (EGFR) is a key driver in the process of squamous cell carcinoma (SCC) cell mitogenesis. Phospholipase C-gamma1 (PLC-gamma1) is a downstream target of EGFR signaling, but the role and necessity of PLC-gamma1 in EGFR-induced cell mitogenesis remain unclear. In the present study, we report an elevated expression of PLC-gamma1 in human SCC biopsies relative to adjacent normal epidermis, and in human SCC cell lines compared to normal human keratinocytes. EGFR… CONTINUE READING

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