Phospholipase C-gamma as a signal-transducing element.

  title={Phospholipase C-gamma as a signal-transducing element.},
  author={Graham F Carpenter and Q s Ji},
  journal={Experimental cell research},
  volume={253 1},
A ubiquitous signaling event in hormonal responses is the phospholipase C (PLC)-catalyzed hydrolysis of phosphatidylinositol 4, 5-bisphosphate to produce the metabolite second messenger molecules inositol 1,4,5-trisphosphate and diacylglycerol. The former provokes a transient increase in intracellular free Ca(2+), while the latter serves as a direct activator of protein kinase C. In tyrosine kinase-dependent signaling pathways this reaction is mediated by the PLC-gamma isozymes. These are… CONTINUE READING